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ChiWriter is a WYSIWYG scientific text editor for DOS. Created by Cay Horstmann in 1986, it was one of the first that could write mathematical formulas on common PC computers.
Mathcad is computer software primarily intended for the verification, validation, documentation and re-use of engineering calculations.
SPSS/PC+ is high end statistics package that supports organizing, analyzing, and graphing data.
Stacker, from Stack Electronics, was a hard drive compression tool. It was wildly popular until Microsoft virtually eliminated the third party market for this by including their own drive compression tool with MS-DOS 6. and Expandz! Plus.
Statpro is a comprehensive statistics system for Apple II, and later IBM PC, computers. It is written using the UCSD P-System.