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Omnis, from the European based Blyth Software, is an easy to use multiuser relational database for Windows, MacOS, and OS/2. It was the first database ported to Microsoft Windows, which ran on Windows 1.0x.
PFS:File is an easy to use flat file database that started off as "PFS: The Personal Filing System" on the Apple II and then ported to the IBM PC, TRS-80, and other platforms. OEM version were available from various companies including IBM. Later it evolved in to PFS:Professional File, and IBM rebranded a version as IBM Filing Assistant.
Pyro, from Fifth Generation Systems, is a commercial set of screen savers that started of as a simple black and white fireworks screen saver on the Apple Macintosh. It competed against AfterDark.
StatWorks, from Cricket Software, is a very powerful statistics software package for the Macintosh designed for a wide variety of applications. It enables all who work with numbers to do statistical computations without spending hours learning "high level" languages or going through several stages to compile analysis.
Unify is a relational database for Unix based systems. There was also a DOS version.
Xerox Globalview is a desktop environment and office suite originally developed for the Xerox Star. It was developed in the MESA programming language on the Xerox Star, and ported to Sun Solaris, OS/2, and Windows 3.1 (The OS/2 version requires a MESA emulator card).