Borland C++ targeted the professional application development market, while Turbo C++ targeted the home and hobbyist market. Borland C++ included additional tools, compiler code-optimization, and documentation to address the needs of commercial developers. In 1997 Borland C++ was replaced with Borland C++ Builder.

Smalltalk/V was the first widely available version of Smalltalk. It was developed by Digitalk in 1986 for DOS, Macintosh, and later Windows.

IBM C Set++ is a set of development tools that include an Presentation Manager based IDE, compiler, PM libraries, debugger, code browser, and on-line help. It later became "IBM VisualAge C++". OS/2 development may also require the IBM Developer's Toolkit.

IBM DB2, or Database 2, is a relational database originally developed for IBM's mainframe systems, and targeted at enterprise customers.

IBM's toolset and libraries for developing OS/2 applications. It may be used with IBM C Set++.

This is IBM's FORTRAN compiler software for the IBM PC. It was written by Microsoft and is similar to the Microsoft FORTRAN Compiler. up until IBM Fortran/2.

IBM Macro Assembler is an IBM OEM rebranded release of Microsoft Macro Assembler, and was intended only for use with the IBM PC.

The Personal Computer BASIC Compiler is a BASIC language compiler written by Microsoft and licensed to IBM for use on the IBM Personal Computer. It is mostly compatible with BASIC code written for IBM Cassette/Disk basic, however the compiled code will run much faster and eliminates the need to distribute source. Compiled programs do not require IBM BASIC in ROM.

The IBM Professional Developers Kit for OS/2 CD contains OS/2 code with the latest fixes, 32-bit graphics engine, support for Microsoft Windows 3.1 programs, online libraries, network code, and tools. This software is intended for use with IBM OS/2 2.0.

IBM VisualAge C++ is a set of development tools that include an IDE, compiler, debugger, code browser, and on-line help. VisualAge C++ is the successor of IBM C Set

IBM VisualAge for Basic delivers a suite of application development tools built around an implementation of the BASIC programming language for developers creating GUI clients and for DB2 application programmer who want to use BASIC to create GUI clients, DB2 stored procedures and user-defined functions. VA Basic is compatible with early Microsoft Visual Basic versions and was available in versions for both 32 bit OS/2 and MS Windows.

VisualAge for Java is an enterprise Java application development environment for teams of Java developers. It was available for Windows and OS/2

VisualAge Smalltalk is a powerful application server and development environment based around the Smalltalk language.

MetaWare High C/C++ is a very robust cross platform compiler for DOS, Unix, OS/2, Windows, and Windows 32. Originally a C compiler targeting CP/M and DOS, 'Metaware High C/C++ was later extended to support OS/2 and the 80386 architecture. After the failure of Metaware it was taken over by MQX Embedded who re-targeted it at the embedded market. MQX Embedded is now Synopsys and the product is now referred as Synopsys Metaware Compiler with no OS/2 version.

Although Microsoft did not invent BASIC, their founding product was a BASIC interpreter for the Altair computer. The descendants below includes Microsoft's BASIC-80 (MBASIC), BASIC-86 (pre-GWBasic), BASIC for Mac, BASIC Compiler 86/88, Basic Compiler for Mac, and Professional Development System 7.x. IBM Personal Computer Basic Compiler, GW-BASIC, QuickBasic, and Visual Basic are listed separately.

This is the original standalone Microsoft C/C++ compiler for DOS and Windows - Later versions were rebranded and renumbered as Microsoft Visual C++ and were bundled with Visual Studio or the SDKs.

The Microsoft OS/2 Programmer's Toolkit 1.0 contains advanced OS/2 1.0 API sample code and documentation for use in conjunction with Microsoft's high-level programming products, sold separately. Software Development Kit, which bundled programming language support and pre-release components.

The Microsoft OS/2 SDK includes pre-release builds of OS/2, beta development tools, sample code, and loads of documentation. These were released prior to the OS/2 1.0 and 1.1 releases. Microsoft charged $3,000 in 1987 for the SDK. It was criticized as overpriced, buggy, and slow.

The Microsoft Pascal Compiler is Microsoft's implementation of the ISO Pascal language for DOS, Xenix, and OS/2. It was among Microsoft's early language products provided for DOS. It was superseded by Microsoft QuickPascal. The Microsoft Pascal Compiler was licensed to IBM, who sold it as the IBM Pascal Compiler.

Microsoft Source Profiler is an application speed analysis tool for use with Microsoft language products. Version 1.x supports both DOS and OS/2.

A database server from Microsoft. It was originally based on Sybase SQL Server, and the first versions were for OS/2. It was available as a standalone product and also as a part of Microsoft BackOffice Server.

These are development tools, mainly SQL Plus, for use with an Oracle Database.

IBM's semi-often correspondence for OS/2 development.

VisPro/C++, from HockWare is a IDE and rapid application development tool for OS/2. Supports several of the more popular C++ compilers including VisualAge and MetaWare.

The Watcom C/C++ is a powerful compiler for DOS, Windows, and OS/2. Its key selling point was superior cross platform support. It supported DOS, extended DOS 32-bit, Win16, Win32, and OS/2. Notably, it was used to produce the video game DOOM as a 32-bit DOS extended program.