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ChiWriter is a WYSIWYG scientific text editor for DOS. Created by Cay Horstmann in 1986, it was one of the first that could write mathematical formulas on common PC computers.
Home Video Producer is a home video title creation program for the IBM PC and compatibles. There were also versions for the Apple II and Commodore 64. It provides fonts, backdrops, animations, and makes use of CGA color artifacting for 16 colors.
Mathcad is computer software primarily intended for the verification, validation, documentation and re-use of engineering calculations.
SPSS/PC+ is high end statistics package that supports organizing, analyzing, and graphing data.
Statpro is a comprehensive statistics system for Apple II, and later IBM PC, computers. It is written using the UCSD P-System.