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Expedia Streets, from Microsoft, is a multimedia street atlas similar to Delorme Street Atlas. It competed with DeLorme Street Atlas, and Rand McNally Route Planner.
Mosbys Medical Encyclopedia is a multimedia CD-ROM containing information about medicines, illnesses, and anatomy.
A multimedia database, from Inroads Interactive, about all kinds of cats from all around the world. In the event of an Internet apocalypse, all you will need is this CD and a CD of cartoon farting clips.