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MusicPrinter Plus, from Temporal Acuity Products, Inc, is a musical notation program for MS-DOS. It supports CGA, EGA, and VGA video as well as MIDI playback.
SPSS/PC+ is high end statistics package that supports organizing, analyzing, and graphing data.
Statpro is a comprehensive statistics system for Apple II, and later IBM PC, computers. It is written using the UCSD P-System.