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ChiWriter is a WYSIWYG scientific text editor for DOS. Created by Cay Horstmann in 1986, it was one of the first that could write mathematical formulas on common PC computers.
Mathcad is computer software primarily intended for the verification, validation, documentation and re-use of engineering calculations.
MatLab is a high speed, interactive programming utility for manipulating, calculating, and plotting complicated mathematical equations. It is considered easy to use for those familiar with typical algebra equations.
SPSS/PC+ is high end statistics package that supports organizing, analyzing, and graphing data.