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Ashlar Vellum is a CAD package for mechanical engineers and designers, that includes the ability to intelligently predict where the user wants to connect the next object. There were both "2D" and "3D" versions.
VideoWorks is a Macintosh animation program that eventually became Macromedia/Adobe Director.
Xerox Globalview is a desktop environment and office suite originally developed for the Xerox Star. It was developed in the MESA programming language on the Xerox Star, and ported to Sun Solaris, OS/2, and Windows 3.1 (The OS/2 version requires a MESA emulator card).