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Mathcad is an easy to use graphical calculation program targeted at engineering professionals. It supports a wide variety of mathematical functions. There were versions for DOS, Macintosh, and Windows.

Mathematica, from Wolfram Research, Inc., is a mathematical and scientific application to formulate
complex equations.
and *Mathworks MatLab*.

MatLab is a high speed, interactive programming utility for manipulating, calculating, and plotting complicated mathematical equations. It is considered easy to use for those familiar with typical algebra equations.