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ChiWriter is a WYSIWYG scientific text editor for DOS. Created by Cay Horstmann in 1986, it was one of the first that could write mathematical formulas on common PC computers.

Derive was a computer algebra and graphing system, developed as a successor to muMATH by Soft Warehouse, Inc. in Honolulu, Hawaii, now owned by Texas Instruments. Derive was implemented in muLISP, also by Soft Warehouse. The first release was in 1988 for DOS. It was discontinued on June 29, 2007 in favor of the TI-Nspire CAS. The last and final version is Derive 6.1 for Windows.

Lighthouse Design Ltd Productivity Applications for NEXTSTEP and OpenStep (1995) 0
Word Processor
Spreadsheet
Presentations
Graphics
Publishing
Communications
Other
Database
Mathematics
Other

Lighthouse Design Ltd Productivity Applications is an application suite of programs for NeXT computers.

Mathcad is an easy to use graphical calculation program targeted at engineering professionals. It supports a wide variety of mathematical functions. There were versions for DOS, Macintosh, and Windows.

Mathematica, from Wolfram Research, Inc., is a mathematical and scientific application to formulate
complex equations.
and *Mathworks MatLab*.

MatLab is a high speed, interactive programming utility for manipulating, calculating, and plotting complicated mathematical equations. It is considered easy to use for those familiar with typical algebra equations.

SPSS/PC+ is high end statistics package that supports organizing, analyzing, and graphing data.